#------------------------------------------------------------------------------
#$Date: 2017-10-13 14:42:48 +0300 (Fri, 13 Oct 2017) $
#$Revision: 201982 $
#$URL: file:///home/coder/svn-repositories/cod/cif/4/02/28/4022843.cif $
#------------------------------------------------------------------------------
#
# This file is available in the Crystallography Open Database (COD),
# http://www.crystallography.net/
#
# All data on this site have been placed in the public domain by the
# contributors.
#
data_4022843
loop_
_publ_author_name
'Ireneusz Nowak'
'Morris J. Robins'
_publ_section_title
;
 Synthesis of 3'-Deoxynucleosides with 2-Oxabicyclo[3.1.0]hexane
 Sugar Moieties: Addition of Difluorocarbene to a 3',4'-Unsaturated
 Uridine Derivative and 1,2-Dihydrofurans Derived from D- and L-Xylose
;
_journal_name_full               'Journal of Organic Chemistry'
_journal_page_first              3319
_journal_page_last               3325
_journal_paper_doi               10.1021/jo062614d
_journal_volume                  72
_journal_year                    2007
_chemical_absolute_configuration ad
_chemical_formula_sum            'C10 H11 F2 N3 O4'
_chemical_formula_weight         275.22
_chemical_name_systematic
; 
 ? 
;
_space_group_IT_number           19
_symmetry_cell_setting           orthorhombic
_symmetry_space_group_name_Hall  'P 2ac 2ab'
_symmetry_space_group_name_H-M   'P 21 21 21'
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_audit_creation_method           SHELXL-97
_cell_angle_alpha                90.00
_cell_angle_beta                 90.00
_cell_angle_gamma                90.00
_cell_formula_units_Z            4
_cell_length_a                   6.2374(4)
_cell_length_b                   9.8577(10)
_cell_length_c                   18.1082(14)
_cell_measurement_reflns_used    80
_cell_measurement_temperature    296(2)
_cell_measurement_theta_max      11.73
_cell_measurement_theta_min      5.13
_cell_volume                     1113.41(16)
_computing_cell_refinement       'Bruker XSCANS'
_computing_data_collection       'Bruker XSCANS'
_computing_data_reduction        'Bruker SHELXTL'
_computing_molecular_graphics    'Bruker SHELXTL'
_computing_publication_material  'Bruker SHELXTL'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 1997)'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 1990)'
_diffrn_ambient_temperature      296(2)
_diffrn_measured_fraction_theta_full 0.997
_diffrn_measured_fraction_theta_max 0.997
_diffrn_measurement_device_type  'Bruker P4'
_diffrn_measurement_method       '2θ/ω scans'
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_type           MoK\a
_diffrn_radiation_wavelength     0.71073
_diffrn_reflns_av_R_equivalents  0.0146
_diffrn_reflns_av_sigmaI/netI    0.0290
_diffrn_reflns_limit_h_max       7
_diffrn_reflns_limit_h_min       -1
_diffrn_reflns_limit_k_max       11
_diffrn_reflns_limit_k_min       -1
_diffrn_reflns_limit_l_max       21
_diffrn_reflns_limit_l_min       -1
_diffrn_reflns_number            1632
_diffrn_reflns_theta_full        24.98
_diffrn_reflns_theta_max         24.98
_diffrn_reflns_theta_min         2.35
_diffrn_standards_interval_count 97
_diffrn_standards_number         3
_exptl_absorpt_coefficient_mu    0.149
_exptl_absorpt_correction_type   none
_exptl_crystal_colour            COLORLESS
_exptl_crystal_density_diffrn    1.642
_exptl_crystal_density_method    'not measured'
_exptl_crystal_description       PRIZM
_exptl_crystal_F_000             568
_exptl_crystal_size_max          0.56
_exptl_crystal_size_mid          0.24
_exptl_crystal_size_min          0.18
_refine_diff_density_max         0.122
_refine_diff_density_min         -0.143
_refine_diff_density_rms         0.033
_refine_ls_abs_structure_details 'Flack H D (1983), Acta Cryst. A39, 876-881'
_refine_ls_abs_structure_Flack   -0.6(11)
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.139
_refine_ls_hydrogen_treatment    mixed
_refine_ls_matrix_type           full
_refine_ls_number_parameters     188
_refine_ls_number_reflns         1162
_refine_ls_number_restraints     0
_refine_ls_restrained_S_all      1.139
_refine_ls_R_factor_all          0.0327
_refine_ls_R_factor_gt           0.0276
_refine_ls_shift/su_max          0.009
_refine_ls_shift/su_mean         0.001
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'calc w=1/[σ²(Fo²)+(0.0396P)²+0.0000P] where P=(Fo²+2Fc²)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.0688
_refine_ls_wR_factor_ref         0.0712
_reflns_number_gt                1056
_reflns_number_total             1162
_reflns_threshold_expression     >2sigma(I)
_cod_data_source_file            jo062614dsi20061219_021704.cif
_cod_data_source_block           xl567
_cod_depositor_comments
;
The following automatic conversions were performed:
'_symmetry_cell_setting' value 'Orthorhombic' changed to 'orthorhombic'
according to '/home/saulius/struct/CIF-dictionaries/cif_core.dic'
dictionary named 'cif_core.dic' version 2.4.1 from 2010-06-29.

Automatic conversion script
Id: cif_fix_enum 1527 2010-12-29 10:47:43Z saulius 
;
_cod_database_code               4022843
loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x+1/2, -y, z+1/2'
'-x, y+1/2, -z+1/2'
'x+1/2, -y+1/2, -z'
loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
_atom_site_refinement_flags
C2 C 0.7172(4) 0.6795(2) 0.28760(12) 0.0344(5) Uani 1 1 d .
C4 C 0.8237(4) 0.4622(2) 0.31738(12) 0.0316(5) Uani 1 1 d .
C5 C 1.0092(4) 0.5123(2) 0.35446(14) 0.0394(6) Uani 1 1 d .
H5 H 1.1102 0.4533 0.3743 0.047 Uiso 1 1 calc R
C6 C 1.0334(4) 0.6470(3) 0.35978(13) 0.0369(6) Uani 1 1 d .
H6 H 1.1529 0.6829 0.3835 0.044 Uiso 1 1 calc R
C1' C 0.8939(4) 0.8806(2) 0.33640(12) 0.0311(5) Uani 1 1 d .
H1' H 0.8952 0.9189 0.2865 0.037 Uiso 1 1 calc R
C2' C 0.7009(4) 0.9410(2) 0.37909(12) 0.0299(5) Uani 1 1 d .
H2'A H 0.5956 0.8711 0.3918 0.036 Uiso 1 1 calc R
C3' C 0.8017(4) 1.0026(3) 0.44768(12) 0.0337(5) Uani 1 1 d .
H3' H 0.7424 1.0870 0.4677 0.040 Uiso 1 1 calc R
C4' C 1.0456(3) 0.9894(2) 0.43857(12) 0.0310(5) Uani 1 1 d .
C5' C 1.2040(4) 1.0981(2) 0.45510(14) 0.0415(6) Uani 1 1 d .
H5'A H 1.1733 1.1361 0.5034 0.050 Uiso 1 1 calc R
H5'B H 1.3466 1.0588 0.4568 0.050 Uiso 1 1 calc R
C6' C 0.9300(4) 0.9141(3) 0.49632(12) 0.0375(5) Uani 1 1 d .
F1 F 0.9070(3) 0.77792(14) 0.49433(8) 0.0488(4) Uani 1 1 d .
F2 F 0.9595(2) 0.9508(2) 0.56723(7) 0.0541(4) Uani 1 1 d .
H2'B H 0.548(6) 1.023(3) 0.3025(18) 0.061(10) Uiso 1 1 d .
H5'C H 1.277(9) 1.184(5) 0.366(3) 0.14(2) Uiso 1 1 d .
H4A H 0.862(5) 0.281(3) 0.3371(17) 0.046(9) Uiso 1 1 d .
H4B H 0.677(5) 0.299(3) 0.2903(16) 0.048(8) Uiso 1 1 d .
N1 N 0.8833(3) 0.73108(18) 0.33053(10) 0.0314(4) Uani 1 1 d .
N3 N 0.6876(4) 0.54430(18) 0.28257(10) 0.0331(4) Uani 1 1 d .
N4 N 0.7881(4) 0.3299(2) 0.31498(14) 0.0427(6) Uani 1 1 d .
O2 O 0.6023(3) 0.76298(17) 0.25518(11) 0.0561(5) Uani 1 1 d .
O2' O 0.6055(3) 1.04933(17) 0.34034(10) 0.0382(4) Uani 1 1 d .
O4' O 1.0860(3) 0.91732(15) 0.37225(8) 0.0335(4) Uani 1 1 d .
O5' O 1.2004(4) 1.20268(19) 0.40204(12) 0.0556(5) Uani 1 1 d .
loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
F F 0.0171 0.0103 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
O2 C2 N3 123.0(2)
O2 C2 N1 116.9(2)
N3 C2 N1 120.0(2)
N4 C4 N3 118.5(2)
N4 C4 C5 119.6(2)
N3 C4 C5 121.95(19)
C6 C5 C4 118.0(2)
C6 C5 H5 121.0
C4 C5 H5 121.0
C5 C6 N1 119.9(2)
C5 C6 H6 120.0
N1 C6 H6 120.0
O4' C1' N1 109.09(19)
O4' C1' C2' 109.35(16)
N1 C1' C2' 112.6(2)
O4' C1' H1' 108.6
N1 C1' H1' 108.6
C2' C1' H1' 108.6
O2' C2' C3' 106.21(19)
O2' C2' C1' 111.77(17)
C3' C2' C1' 103.91(18)
O2' C2' H2'A 111.5
C3' C2' H2'A 111.5
C1' C2' H2'A 111.5
C6' C3' C2' 118.4(2)
C6' C3' C4' 58.45(16)
C2' C3' C4' 106.75(19)
C6' C3' H3' 119.1
C2' C3' H3' 119.1
C4' C3' H3' 119.1
O4' C4' C6' 115.9(2)
O4' C4' C5' 114.41(19)
C6' C4' C5' 123.1(2)
O4' C4' C3' 108.03(19)
C6' C4' C3' 58.73(16)
C5' C4' C3' 125.1(2)
O5' C5' C4' 112.3(2)
O5' C5' H5'A 109.2
C4' C5' H5'A 109.2
O5' C5' H5'B 109.2
C4' C5' H5'B 109.2
H5'A C5' H5'B 107.9
F2 C6' F1 107.89(19)
F2 C6' C4' 118.4(2)
F1 C6' C4' 122.3(2)
F2 C6' C3' 119.0(2)
F1 C6' C3' 120.9(2)
C4' C6' C3' 62.82(15)
C6 N1 C2 120.57(19)
C6 N1 C1' 123.3(2)
C2 N1 C1' 115.93(19)
C4 N3 C2 118.8(2)
C4 N4 H4A 120(2)
C4 N4 H4B 119.6(18)
H4A N4 H4B 121(3)
C2' O2' H2'B 111(2)
C1' O4' C4' 111.58(17)
C5' O5' H5'C 112(4)
loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
C2 O2 1.239(3)
C2 N3 1.349(3)
C2 N1 1.391(3)
C4 N4 1.323(3)
C4 N3 1.332(3)
C4 C5 1.426(4)
C5 C6 1.340(3)
C5 H5 0.9300
C6 N1 1.358(3)
C6 H6 0.9300
C1' O4' 1.410(3)
C1' N1 1.479(3)
C1' C2' 1.550(3)
C1' H1' 0.9800
C2' O2' 1.409(3)
C2' C3' 1.519(3)
C2' H2'A 0.9800
C3' C6' 1.476(3)
C3' C4' 1.536(3)
C3' H3' 0.9800
C4' O4' 1.418(3)
C4' C6' 1.471(3)
C4' C5' 1.488(3)
C5' O5' 1.410(3)
C5' H5'A 0.9700
C5' H5'B 0.9700
C6' F2 1.347(3)
C6' F1 1.351(3)
N4 H4A 0.78(3)
N4 H4B 0.88(3)
O2' H2'B 0.81(3)
O5' H5'C 0.83(5)
loop_
_geom_hbond_atom_site_label_D
_geom_hbond_atom_site_label_H
_geom_hbond_atom_site_label_A
_geom_hbond_distance_DH
_geom_hbond_distance_HA
_geom_hbond_distance_DA
_geom_hbond_angle_DHA
_geom_hbond_site_symmetry_A
O5' H5'C O2' 0.83(5) 2.48(6) 3.150(3) 138(5) 1_655
O5' H5'C O2 0.83(5) 2.44(5) 3.158(3) 144(5) 3_755
O2' H2'B N3 0.81(3) 2.14(3) 2.881(3) 151(3) 3_655
N4 H4A O5' 0.78(3) 2.53(3) 3.267(4) 157(3) 1_545
N4 H4B O2 0.88(3) 1.96(3) 2.825(3) 167(3) 3_645
loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
N4 C4 C5 C6 -176.0(3)
N3 C4 C5 C6 6.4(4)
C4 C5 C6 N1 0.2(4)
O4' C1' C2' O2' 108.0(2)
N1 C1' C2' O2' -130.56(19)
O4' C1' C2' C3' -6.1(2)
N1 C1' C2' C3' 115.3(2)
O2' C2' C3' C6' -175.00(19)
C1' C2' C3' C6' -57.0(2)
O2' C2' C3' C4' -112.3(2)
C1' C2' C3' C4' 5.7(3)
C6' C3' C4' O4' 109.8(2)
C2' C3' C4' O4' -3.7(3)
C2' C3' C4' C6' -113.5(2)
C6' C3' C4' C5' -110.7(3)
C2' C3' C4' C5' 135.8(2)
O4' C4' C5' O5' 64.4(3)
C6' C4' C5' O5' -145.5(2)
C3' C4' C5' O5' -72.9(3)
O4' C4' C6' F2 153.8(2)
C5' C4' C6' F2 4.1(3)
C3' C4' C6' F2 -110.0(2)
O4' C4' C6' F1 14.9(3)
C5' C4' C6' F1 -134.9(2)
C3' C4' C6' F1 111.1(3)
O4' C4' C6' C3' -96.2(2)
C5' C4' C6' C3' 114.0(3)
C2' C3' C6' F2 -158.0(2)
C4' C3' C6' F2 109.0(2)
C2' C3' C6' F1 -20.1(3)
C4' C3' C6' F1 -113.1(3)
C2' C3' C6' C4' 93.0(2)
C5 C6 N1 C2 -7.5(4)
C5 C6 N1 C1' 177.7(2)
O2 C2 N1 C6 -171.2(2)
N3 C2 N1 C6 8.6(3)
O2 C2 N1 C1' 4.0(3)
N3 C2 N1 C1' -176.2(2)
O4' C1' N1 C6 3.4(3)
C2' C1' N1 C6 -118.2(2)
O4' C1' N1 C2 -171.61(17)
C2' C1' N1 C2 66.8(2)
N4 C4 N3 C2 177.0(2)
C5 C4 N3 C2 -5.4(3)
O2 C2 N3 C4 177.7(2)
N1 C2 N3 C4 -2.1(4)
N1 C1' O4' C4' -119.44(19)
C2' C1' O4' C4' 4.1(2)
C6' C4' O4' C1' 63.0(2)
C5' C4' O4' C1' -144.6(2)
C3' C4' O4' C1' -0.3(3)
loop_
_cod_related_entry_id
_cod_related_entry_database
_cod_related_entry_code
1 ChemSpider 17343567
