#------------------------------------------------------------------------------ #$Date: 2016-04-03 06:35:56 +0300 (Sun, 03 Apr 2016) $ #$Revision: 181259 $ #$URL: file:///home/coder/svn-repositories/cod/hkl/2/23/37/2233704.hkl $ #------------------------------------------------------------------------------ # # This file is available in the Crystallography Open Database (COD), # http://www.crystallography.net/. The original data for this entry # were provided by IUCr Journals, http://journals.iucr.org/. # # The file may be used within the scientific community so long as # proper attribution is given to the journal article from which the # data were obtained. # data_2233704_Fobs loop_ _publ_author_name 'van Albada, Gerard A.' 'Ghazzali, Mohamed' 'Al-Farhan, Khalid' 'Reedijk, Jan' _publ_section_title ; 2-Chloropyrimidin-4-amine ; _journal_coeditor_code ZJ2047 _journal_issue 2 _journal_name_full 'Acta Crystallographica Section E' _journal_page_first o302 _journal_volume 68 _journal_year 2012 _space_group_IT_number 14 _symmetry_space_group_name_Hall '-P 2ybc' _symmetry_space_group_name_H-M 'P 1 21/c 1' _cell_angle_alpha 90.000 _cell_angle_beta 100.886 _cell_angle_gamma 90.000 _cell_length_a 3.8316 _cell_length_b 11.8651 _cell_length_c 12.7608 _exptl_crystal_F_000 264.00 _reflns_d_resolution_high 0.7701 _cod_data_source_file zj2047Isup2.hkl _cod_data_source_block I #BEGIN Tags that were not found in dictionaries: _shelx_title ' jr242 in P21/c' _shelx_refln_list_code 4 _shelx_f_calc_maximum 90.57 _shelx_f_squared_multiplier 1.000 #END Tags that were not found in dictionaries loop_ _symmetry_equiv_pos_as_xyz 'x, y, z' '-x, y+1/2, -z+1/2' '-x, -y, -z' 'x, -y-1/2, z-1/2' loop_ _refln_index_h _refln_index_k _refln_index_l _refln_F_squared_calc _refln_F_squared_meas _refln_F_squared_sigma _refln_observed_status 1 0 0 529.71 504.94 4.08 o 2 0 0 0.61 0.29 0.24 o 3 0 0 4.08 3.72 0.56 o 4 0 0 1.33 0.78 1.84 o 1 1 0 8202.11 7239.79 162.42 o 2 1 0 2.38 2.63 0.22 o 3 1 0 21.34 24.15 1.01 o 4 1 0 6.82 2.79 1.65 o 0 2 0 807.45 774.98 6.13 o 1 2 0 5010.92 4883.86 50.15 o 2 2 0 213.65 204.75 2.63 o 3 2 0 0.76 1.26 0.56 o 4 2 0 0.01 0.02 0.45 o 1 3 0 442.68 435.84 3.29 o 2 3 0 1934.51 2002.08 15.15 o 3 3 0 10.35 11.31 0.83 o 4 3 0 8.24 5.12 1.39 o 0 4 0 575.53 529.23 6.19 o 1 4 0 767.79 829.87 5.33 o 2 4 0 307.53 318.17 2.73 o 3 4 0 130.96 134.60 2.84 o 4 4 0 7.15 6.05 1.62 o 1 5 0 19.77 20.11 0.53 o 2 5 0 4.60 7.60 0.66 o 3 5 0 316.94 318.80 5.32 o 4 5 0 47.40 55.95 3.28 o 0 6 0 533.57 534.95 5.46 o 1 6 0 227.37 203.89 1.81 o 2 6 0 174.53 184.65 2.23 o 3 6 0 26.97 33.21 5.96 o 4 6 0 22.72 14.41 2.46 o 1 7 0 42.19 43.61 0.93 o 2 7 0 1.59 1.73 0.66 o 3 7 0 0.07 0.47 0.45 o 4 7 0 3.75 2.35 1.62 o 0 8 0 49.30 43.18 1.57 o 1 8 0 153.06 149.06 1.84 o 2 8 0 246.63 260.95 3.62 o 3 8 0 14.49 15.26 1.06 o 4 8 0 5.10 2.71 3.15 o 1 9 0 43.20 47.62 1.18 o 2 9 0 3.62 3.06 0.94 o 3 9 0 21.89 22.37 1.68 o 0 10 0 143.56 148.52 3.92 o 1 10 0 60.15 65.93 1.70 o 2 10 0 1.31 0.45 0.85 o 3 10 0 16.87 15.62 4.47 o 1 11 0 24.77 24.20 1.80 o 2 11 0 0.98 0.86 0.63 o 3 11 0 0.02 0.69 2.26 o 0 12 0 0.33 0.00 1.43 o 1 12 0 1.07 0.67 0.79 o 2 12 0 7.21 7.07 1.48 o 3 12 0 4.40 4.04 4.42 o 1 13 0 0.25 0.23 0.83 o 2 13 0 9.61 9.07 1.64 o 0 14 0 0.06 0.24 1.50 o 1 14 0 6.29 2.71 1.64 o 2 14 0 4.23 4.96 2.86 o 1 15 0 1.75 0.94 1.34 o -4 1 1 14.46 17.93 3.59 o -3 1 1 271.04 286.36 3.65 o -2 1 1 1980.99 2010.43 19.35 o -1 1 1 149.45 150.34 2.88 o 1 1 1 986.28 1001.65 5.22 o 2 1 1 0.30 0.58 0.24 o 3 1 1 16.51 16.67 0.65 o 4 1 1 17.52 14.98 2.86 o -4 2 1 6.78 6.72 1.16 o -3 2 1 94.92 101.87 2.39 o -2 2 1 431.54 437.47 4.60 o -1 2 1 7353.33 7083.93 66.85 o 0 2 1 2020.13 1987.31 11.48 o 1 2 1 0.59 0.65 0.20 o 2 2 1 34.35 40.16 0.69 o 3 2 1 121.76 135.06 2.28 o 4 2 1 2.75 2.14 0.89 o -4 3 1 28.29 27.79 3.10 o -3 3 1 36.19 34.12 1.10 o -2 3 1 415.50 430.99 6.61 o -1 3 1 692.71 682.22 4.62 o 0 3 1 758.54 694.36 3.89 o 1 3 1 558.91 564.22 3.81 o 2 3 1 425.76 427.40 3.73 o 3 3 1 53.03 58.28 1.75 o 4 3 1 0.00 0.73 1.43 o -4 4 1 17.23 8.34 3.09 o -3 4 1 96.49 98.28 2.53 o -2 4 1 235.61 230.13 2.25 o -1 4 1 498.12 496.27 3.36 o 0 4 1 2337.06 2270.89 14.23 o 1 4 1 1055.09 1039.79 7.27 o 2 4 1 638.45 639.81 5.77 o 3 4 1 7.40 6.21 1.04 o 4 4 1 14.13 15.04 2.10 o -4 5 1 3.31 1.41 1.72 o -3 5 1 174.41 178.79 3.51 o -2 5 1 17.42 17.46 0.66 o -1 5 1 173.69 184.93 1.65 o 0 5 1 761.74 770.03 5.26 o 1 5 1 0.04 0.07 0.20 o 2 5 1 63.01 68.19 1.24 o 3 5 1 0.81 0.89 0.79 o 4 5 1 6.33 3.31 1.46 o -4 6 1 14.63 9.29 2.47 o -3 6 1 9.00 12.35 1.67 o -2 6 1 13.26 12.74 0.71 o -1 6 1 11.53 17.86 0.61 o 0 6 1 243.67 222.60 2.16 o 1 6 1 1307.96 1302.26 9.37 o 2 6 1 102.33 105.12 1.69 o 3 6 1 93.43 97.09 1.82 o 4 6 1 8.25 6.23 1.53 o -4 7 1 40.31 46.41 7.37 o -3 7 1 23.49 26.94 2.52 o -2 7 1 51.55 55.15 1.38 o -1 7 1 19.75 16.67 0.74 o 0 7 1 653.23 687.00 5.36 o 1 7 1 47.70 46.92 1.13 o 2 7 1 53.79 53.24 1.43 o 3 7 1 53.49 55.67 1.80 o 4 7 1 10.67 9.92 3.65 o -4 8 1 0.48 0.91 1.54 o -3 8 1 4.50 3.83 0.82 o -2 8 1 30.77 32.74 2.19 o -1 8 1 24.93 28.41 0.99 o 0 8 1 0.61 1.19 0.51 o 1 8 1 32.12 37.55 0.98 o 2 8 1 30.40 32.36 1.34 o 3 8 1 0.02 -0.16 0.52 o 4 8 1 5.50 7.11 4.41 o -4 9 1 0.06 -0.32 2.44 o -3 9 1 1.05 1.52 0.65 o -2 9 1 61.60 61.60 1.90 o -1 9 1 176.19 180.04 2.41 o 0 9 1 1.59 1.12 0.64 o 1 9 1 25.85 27.86 1.03 o 2 9 1 18.21 18.51 1.27 o 3 9 1 18.35 16.42 2.52 o -3 10 1 0.18 2.15 2.22 o -2 10 1 2.34 2.17 0.62 o -1 10 1 55.86 50.62 1.56 o 0 10 1 48.45 48.49 1.44 o 1 10 1 61.71 59.54 1.68 o 2 10 1 54.00 55.55 1.87 o 3 10 1 1.96 3.22 1.62 o -3 11 1 5.99 3.81 1.85 o -2 11 1 0.26 1.03 0.69 o -1 11 1 5.33 4.65 0.93 o 0 11 1 8.15 7.55 1.02 o 1 11 1 4.97 4.39 0.95 o 2 11 1 0.40 0.69 0.91 o 3 11 1 0.43 2.73 1.92 o -3 12 1 0.10 2.40 3.00 o -2 12 1 3.47 4.04 1.34 o -1 12 1 3.13 3.80 1.09 o 0 12 1 103.01 109.26 2.83 o 1 12 1 34.24 36.18 1.52 o 2 12 1 15.86 16.00 2.72 o -2 13 1 0.01 2.28 1.24 o -1 13 1 17.68 9.72 2.67 o 0 13 1 1.52 0.55 0.84 o 1 13 1 4.35 3.57 1.35 o 2 13 1 0.55 2.36 1.70 o -2 14 1 2.81 2.14 1.56 o -1 14 1 6.56 3.19 1.41 o 0 14 1 0.47 0.62 1.28 o 1 14 1 20.85 16.45 5.12 o -1 15 1 0.02 0.90 1.46 o 0 15 1 7.09 6.81 1.82 o 1 15 1 3.92 4.76 4.16 o -4 0 2 59.67 66.31 4.60 o -3 0 2 100.73 100.91 3.96 o -2 0 2 28.60 26.69 0.88 o -1 0 2 3623.69 3525.23 43.21 o 0 0 2 315.91 333.01 2.31 o 1 0 2 1019.88 916.28 6.90 o 2 0 2 652.84 632.88 6.11 o 3 0 2 92.27 95.73 2.14 o 4 0 2 22.06 22.15 15.13 o -4 1 2 35.03 37.84 10.84 o -3 1 2 47.28 50.21 1.43 o -2 1 2 27.25 28.77 1.19 o -1 1 2 439.27 436.75 3.33 o 0 1 2 985.72 965.72 5.33 o 1 1 2 733.71 706.84 3.76 o 2 1 2 19.71 20.27 0.57 o 3 1 2 0.98 0.91 0.45 o 4 1 2 5.61 2.39 1.28 o -4 2 2 0.52 1.00 0.67 o -3 2 2 33.57 36.39 1.22 o -2 2 2 527.11 547.18 7.22 o -1 2 2 0.58 0.80 0.33 o 0 2 2 1702.09 1563.80 9.77 o 1 2 2 1024.38 989.64 5.82 o 2 2 2 153.05 148.10 1.47 o 3 2 2 48.21 47.94 1.09 o 4 2 2 7.54 7.46 1.29 o -4 3 2 12.38 8.07 1.66 o -3 3 2 374.64 386.41 4.56 o -2 3 2 364.78 366.95 3.76 o -1 3 2 0.39 1.48 0.29 o 0 3 2 1203.66 1126.83 6.98 o 1 3 2 1.67 1.07 0.15 o 2 3 2 0.59 0.68 0.30 o 3 3 2 11.42 12.28 0.61 o 4 3 2 0.15 -0.55 0.88 o -4 4 2 3.46 1.99 1.47 o -3 4 2 7.42 6.84 1.26 o -2 4 2 427.62 460.43 5.25 o -1 4 2 96.70 101.74 1.02 o 0 4 2 270.21 271.78 1.94 o 1 4 2 0.07 0.09 0.16 o 2 4 2 6.76 5.11 0.36 o 3 4 2 6.99 8.06 0.75 o 4 4 2 3.01 1.40 1.29 o -4 5 2 68.84 75.45 3.61 o -3 5 2 5.99 6.79 1.28 o -2 5 2 272.09 256.57 2.93 o -1 5 2 1341.43 1346.22 8.63 o 0 5 2 101.95 86.59 1.01 o 1 5 2 4.51 6.42 0.57 o 2 5 2 1.24 1.47 0.29 o 3 5 2 18.67 18.48 0.94 o 4 5 2 26.59 26.51 2.68 o -4 6 2 3.10 0.11 1.08 o -3 6 2 35.77 37.82 2.05 o -2 6 2 0.92 1.81 0.55 o -1 6 2 141.07 143.72 1.76 o 0 6 2 536.50 540.87 4.21 o 1 6 2 42.03 42.13 0.72 o 2 6 2 19.85 20.14 0.92 o 3 6 2 66.44 72.30 1.49 o 4 6 2 2.64 3.27 2.34 o -4 7 2 15.14 4.22 2.69 o -3 7 2 45.06 49.90 2.68 o -2 7 2 95.73 97.07 1.93 o -1 7 2 51.91 46.20 0.99 o 0 7 2 77.44 76.23 1.28 o 1 7 2 77.92 79.13 1.21 o 2 7 2 68.26 69.84 1.58 o 3 7 2 14.57 14.18 0.80 o 4 7 2 1.39 3.28 3.05 o -4 8 2 8.71 6.68 2.14 o -3 8 2 7.24 6.09 0.77 o -2 8 2 27.56 24.28 1.22 o -1 8 2 194.65 187.97 2.30 o 0 8 2 135.46 124.64 1.75 o 1 8 2 376.00 374.27 3.63 o 2 8 2 207.53 217.02 3.09 o 3 8 2 6.15 6.55 1.00 o 4 8 2 4.41 7.07 3.20 o -4 9 2 0.13 -1.39 2.77 o -3 9 2 24.91 22.08 2.76 o -2 9 2 3.55 4.15 1.10 o -1 9 2 0.30 0.34 0.51 o 0 9 2 2.41 1.67 0.57 o 1 9 2 40.28 40.07 1.32 o 2 9 2 12.84 11.72 0.66 o 3 9 2 2.07 0.97 1.15 o -3 10 2 10.04 8.27 3.11 o -2 10 2 2.95 1.16 0.65 o -1 10 2 22.81 21.46 1.21 o 0 10 2 203.63 204.22 2.95 o 1 10 2 69.30 71.11 2.07 o 2 10 2 39.57 40.40 1.62 o 3 10 2 19.77 14.96 5.22 o -3 11 2 6.40 9.51 2.76 o -2 11 2 77.63 77.18 2.00 o -1 11 2 71.49 70.37 1.81 o 0 11 2 19.28 20.22 1.25 o 1 11 2 1.88 1.05 0.66 o 2 11 2 5.76 8.01 1.76 o 3 11 2 18.09 17.02 3.11 o -3 12 2 0.54 2.39 2.37 o -2 12 2 0.98 0.71 1.11 o -1 12 2 3.78 1.79 1.17 o 0 12 2 0.02 0.25 0.73 o 1 12 2 25.74 26.19 3.38 o 2 12 2 0.06 1.51 1.41 o -2 13 2 14.51 17.07 3.38 o -1 13 2 39.19 43.78 2.24 o 0 13 2 43.36 45.38 2.74 o 1 13 2 0.30 0.72 1.03 o 2 13 2 16.49 16.36 2.77 o -2 14 2 1.85 1.95 1.50 o -1 14 2 2.46 1.94 1.36 o 0 14 2 12.25 7.20 1.67 o 1 14 2 28.58 32.99 3.82 o -1 15 2 2.76 4.46 1.78 o 0 15 2 0.31 0.34 1.03 o -4 1 3 27.48 25.81 5.57 o -3 1 3 168.24 165.68 5.10 o -2 1 3 513.84 483.81 4.24 o -1 1 3 1541.79 1436.32 11.58 o 0 1 3 780.45 770.26 4.61 o 1 1 3 40.19 40.26 0.67 o 2 1 3 44.54 49.11 1.03 o 3 1 3 0.27 0.04 0.36 o 4 1 3 3.01 2.55 1.08 o -4 2 3 7.04 3.73 1.57 o -3 2 3 1.65 1.48 0.63 o -2 2 3 16.39 15.97 0.67 o -1 2 3 67.27 59.27 0.79 o 0 2 3 1917.63 1802.73 11.90 o 1 2 3 47.38 39.50 0.59 o 2 2 3 84.31 80.57 1.12 o 3 2 3 46.38 50.03 1.38 o 4 2 3 49.72 56.73 2.27 o -4 3 3 3.70 2.03 0.79 o -3 3 3 5.27 4.47 0.80 o -2 3 3 165.49 160.83 1.85 o -1 3 3 26.95 28.84 0.62 o 0 3 3 306.52 284.24 2.09 o 1 3 3 358.60 355.78 2.96 o 2 3 3 14.00 15.27 0.74 o 3 3 3 16.47 16.33 1.72 o 4 3 3 20.36 13.17 4.21 o -4 4 3 1.22 0.73 1.02 o -3 4 3 3.62 5.06 1.14 o -2 4 3 0.22 0.38 0.24 o -1 4 3 442.16 418.86 3.37 o 0 4 3 51.54 41.87 0.83 o 1 4 3 1008.94 969.22 7.07 o 2 4 3 301.83 302.07 2.47 o 3 4 3 198.44 212.82 2.65 o 4 4 3 6.09 5.28 1.78 o -4 5 3 2.54 0.67 1.29 o -3 5 3 0.03 -0.06 0.72 o -2 5 3 104.11 109.14 1.63 o -1 5 3 0.87 1.02 0.33 o 0 5 3 25.47 28.11 0.67 o 1 5 3 43.01 46.74 1.07 o 2 5 3 17.94 19.11 0.55 o 3 5 3 25.10 25.56 1.09 o 4 5 3 15.28 8.56 3.70 o -4 6 3 6.05 0.95 1.24 o -3 6 3 0.01 0.29 0.95 o -2 6 3 5.00 4.64 0.67 o -1 6 3 0.04 0.41 0.37 o 0 6 3 369.06 363.45 2.95 o 1 6 3 225.96 219.86 2.18 o 2 6 3 424.85 429.90 3.35 o 3 6 3 4.09 3.77 0.70 o 4 6 3 0.14 1.82 2.58 o -4 7 3 17.24 3.51 3.12 o -3 7 3 43.01 48.26 2.50 o -2 7 3 20.31 22.53 0.99 o -1 7 3 301.34 308.35 3.26 o 0 7 3 179.80 178.85 2.01 o 1 7 3 267.21 259.79 2.45 o 2 7 3 13.85 14.96 0.86 o 3 7 3 52.13 47.16 1.30 o 4 7 3 1.66 1.67 2.47 o -4 8 3 3.64 3.96 2.17 o -3 8 3 22.63 21.52 1.32 o -2 8 3 5.88 4.67 0.85 o -1 8 3 21.16 22.81 1.05 o 0 8 3 33.17 29.87 1.01 o 1 8 3 116.37 112.64 1.62 o 2 8 3 43.59 44.43 1.46 o 3 8 3 1.84 1.22 0.90 o -4 9 3 1.55 2.23 1.82 o -3 9 3 61.05 63.96 2.35 o -2 9 3 142.54 153.36 3.08 o -1 9 3 67.42 72.93 1.68 o 0 9 3 342.16 340.86 3.69 o 1 9 3 0.12 0.53 0.44 o 2 9 3 21.23 18.70 1.06 o 3 9 3 1.42 2.53 1.20 o -3 10 3 1.42 2.43 2.15 o -2 10 3 36.85 36.55 1.57 o -1 10 3 21.42 23.03 1.63 o 0 10 3 0.86 1.18 0.66 o 1 10 3 159.85 158.44 2.33 o 2 10 3 17.80 19.69 1.27 o 3 10 3 5.98 4.72 2.41 o -3 11 3 1.39 4.54 2.55 o -2 11 3 56.42 68.76 5.96 o -1 11 3 150.35 157.62 2.94 o 0 11 3 39.10 34.61 1.43 o 1 11 3 0.97 0.74 0.58 o 2 11 3 2.21 2.77 1.41 o 3 11 3 0.26 1.80 2.58 o -3 12 3 1.86 3.27 2.01 o -2 12 3 17.54 14.65 2.01 o -1 12 3 107.68 107.12 2.89 o 0 12 3 84.01 84.46 2.37 o 1 12 3 21.70 21.96 2.92 o 2 12 3 14.04 16.74 2.83 o -2 13 3 1.38 2.95 1.69 o -1 13 3 21.97 13.39 3.92 o 0 13 3 7.56 5.58 1.44 o 1 13 3 7.50 4.51 1.51 o 2 13 3 2.43 5.65 1.83 o -2 14 3 2.15 4.65 5.62 o -1 14 3 1.53 1.96 1.36 o 0 14 3 29.91 24.93 4.49 o 1 14 3 8.93 5.71 2.07 o 0 15 3 5.01 3.04 1.58 o -4 0 4 10.24 1.67 2.36 o -3 0 4 18.04 18.52 0.86 o -2 0 4 144.29 153.99 2.72 o -1 0 4 332.61 314.09 4.86 o 0 0 4 206.16 209.15 2.99 o 1 0 4 0.15 0.79 0.39 o 2 0 4 461.66 456.12 4.93 o 3 0 4 519.90 529.63 7.62 o 4 0 4 19.00 25.65 4.08 o -4 1 4 10.98 3.63 2.10 o -3 1 4 0.01 -0.16 0.49 o -2 1 4 102.11 95.70 1.65 o -1 1 4 400.55 423.58 3.97 o 0 1 4 43.71 44.74 0.56 o 1 1 4 63.84 58.13 0.73 o 2 1 4 464.77 485.43 3.88 o 3 1 4 2.30 1.39 0.58 o 4 1 4 8.99 5.94 1.97 o -4 2 4 15.20 15.12 1.62 o -3 2 4 37.93 40.14 1.88 o -2 2 4 19.81 22.47 0.74 o -1 2 4 40.33 39.15 0.90 o 0 2 4 1.28 4.09 0.35 o 1 2 4 1166.42 1200.58 7.51 o 2 2 4 254.23 260.61 2.54 o 3 2 4 15.40 16.87 1.67 o 4 2 4 18.54 12.25 3.27 o -4 3 4 2.06 0.94 0.61 o -3 3 4 138.92 145.89 3.29 o -2 3 4 317.31 308.96 3.00 o -1 3 4 119.20 107.51 1.34 o 0 3 4 1692.10 1699.30 12.14 o 1 3 4 1150.64 1206.28 8.91 o 2 3 4 26.60 26.53 0.83 o 3 3 4 9.11 10.59 1.25 o 4 3 4 23.71 13.64 5.19 o -4 4 4 0.54 0.09 0.77 o -3 4 4 1.55 1.84 0.73 o -2 4 4 61.30 64.36 1.18 o -1 4 4 1.93 2.47 0.47 o 0 4 4 733.33 816.66 5.82 o 1 4 4 0.01 0.36 0.37 o 2 4 4 10.48 10.42 0.44 o 3 4 4 25.89 29.08 1.10 o 4 4 4 17.53 8.48 4.58 o -4 5 4 6.85 3.43 1.81 o -3 5 4 31.27 36.13 2.02 o -2 5 4 108.61 108.70 1.72 o -1 5 4 1490.54 1461.38 10.46 o 0 5 4 781.17 784.57 5.86 o 1 5 4 229.03 217.17 2.62 o 2 5 4 7.93 7.83 0.87 o 3 5 4 81.28 78.23 1.58 o 4 5 4 4.21 1.58 2.25 o -4 6 4 0.63 0.12 1.00 o -3 6 4 1.83 1.86 1.38 o -2 6 4 33.42 32.90 0.93 o -1 6 4 86.41 93.25 1.49 o 0 6 4 70.75 71.31 1.19 o 1 6 4 23.58 22.61 1.08 o 2 6 4 515.88 524.21 5.59 o 3 6 4 14.64 13.19 1.02 o 4 6 4 2.73 0.77 2.35 o -4 7 4 5.62 3.18 2.28 o -3 7 4 3.47 3.26 0.50 o -2 7 4 156.36 162.76 2.61 o -1 7 4 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