#------------------------------------------------------------------------------
#$Date: 2025-08-22 17:55:42 +0300 (Fri, 22 Aug 2025) $
#$Revision: 301864 $
#$URL: file:///home/coder/svn-repositories/cod/cif/7/21/76/7217661.cif $
#------------------------------------------------------------------------------
#
# This file is available in the Crystallography Open Database (COD),
# http://www.crystallography.net/
#
# All data on this site have been placed in the public domain by the
# contributors.
#
data_7217661
loop_
_publ_author_name
'Thorat, Shridhar H.'
'Patwadkar, Manjusha V.'
'Gonnade, Rajesh G.'
'Vaidhyanathan, R.'
_publ_section_title
;
 Capturing a novel metastable polymorph of the anticancer drug gefitinib
;
_journal_issue                   37
_journal_name_full               CrystEngComm
_journal_page_first              8638
_journal_paper_doi               10.1039/C4CE01446D
_journal_volume                  16
_journal_year                    2014
_chemical_formula_moiety         'C22 H24 Cl F N4 O3'
_chemical_formula_sum            'C22 H24 Cl F N4 O3'
_chemical_formula_weight         446.90
_chemical_melting_point          466.5(5)
_chemical_name_common            Iressa
_chemical_name_systematic        Gefitinib
_space_group_IT_number           2
_symmetry_cell_setting           triclinic
_symmetry_space_group_name_Hall  '-P 1'
_symmetry_space_group_name_H-M   'P -1'
_atom_sites_solution_hydrogens   geom
_atom_sites_solution_primary     direct
_atom_sites_solution_secondary   difmap
_audit_creation_method           SHELXL-97
_cell_angle_alpha                93.700(2)
_cell_angle_beta                 97.546(2)
_cell_angle_gamma                101.939(2)
_cell_formula_units_Z            2
_cell_length_a                   8.8091(4)
_cell_length_b                   9.6702(4)
_cell_length_c                   12.4941(5)
_cell_measurement_reflns_used    9933
_cell_measurement_temperature    100(2)
_cell_measurement_theta_max      41.42
_cell_measurement_theta_min      2.70
_cell_volume                     1027.65(8)
_computing_cell_refinement       'Bruker SAINT'
_computing_data_collection       'Bruker APEX2'
_computing_data_reduction        'Bruker SAINT'
_computing_molecular_graphics    'Bruker SHELXTL'
_computing_publication_material  'Bruker SHELXTL'
_computing_structure_refinement  'SHELXL-97 (Sheldrick, 2008)'
_computing_structure_solution    'SHELXS-97 (Sheldrick, 2008)'
_diffrn_ambient_temperature      100(2)
_diffrn_measured_fraction_theta_full 0.998
_diffrn_measured_fraction_theta_max 0.998
_diffrn_measurement_device_type  'Bruker APEX-II CCD'
_diffrn_measurement_method       'φ and ω scans'
_diffrn_radiation_monochromator  graphite
_diffrn_radiation_source         'fine-focus sealed tube'
_diffrn_radiation_type           MoK\a
_diffrn_radiation_wavelength     0.71073
_diffrn_reflns_av_R_equivalents  0.0155
_diffrn_reflns_av_sigmaI/netI    0.0116
_diffrn_reflns_limit_h_max       10
_diffrn_reflns_limit_h_min       -10
_diffrn_reflns_limit_k_max       11
_diffrn_reflns_limit_k_min       -11
_diffrn_reflns_limit_l_max       15
_diffrn_reflns_limit_l_min       -15
_diffrn_reflns_number            19219
_diffrn_reflns_theta_full        26.00
_diffrn_reflns_theta_max         26.00
_diffrn_reflns_theta_min         1.65
_exptl_absorpt_coefficient_mu    0.228
_exptl_absorpt_correction_T_max  0.9264
_exptl_absorpt_correction_T_min  0.8847
_exptl_absorpt_correction_type   multi-scan
_exptl_absorpt_process_details   'Bruker SADABS'
_exptl_crystal_colour            Colourless
_exptl_crystal_density_diffrn    1.444
_exptl_crystal_density_method    'not measured'
_exptl_crystal_description       block
_exptl_crystal_F_000             468
_exptl_crystal_recrystallization_method
'Re-crystallisation from solvent: Ethyl acetate'
_exptl_crystal_size_max          0.55
_exptl_crystal_size_mid          0.47
_exptl_crystal_size_min          0.34
_refine_diff_density_max         0.296
_refine_diff_density_min         -0.235
_refine_diff_density_rms         0.038
_refine_ls_extinction_method     none
_refine_ls_goodness_of_fit_ref   1.019
_refine_ls_hydrogen_treatment    refall
_refine_ls_matrix_type           full
_refine_ls_number_parameters     376
_refine_ls_number_reflns         4014
_refine_ls_number_restraints     0
_refine_ls_restrained_S_all      1.019
_refine_ls_R_factor_all          0.0297
_refine_ls_R_factor_gt           0.0277
_refine_ls_shift/su_max          0.001
_refine_ls_shift/su_mean         0.000
_refine_ls_structure_factor_coef Fsqd
_refine_ls_weighting_details
'calc w=1/[σ²(Fo²)+(0.0349P)²+0.5056P] where P=(Fo²+2Fc²)/3'
_refine_ls_weighting_scheme      calc
_refine_ls_wR_factor_gt          0.0718
_refine_ls_wR_factor_ref         0.0738
_reflns_number_gt                3758
_reflns_number_total             4014
_reflns_threshold_expression     >2sigma(I)
_cod_data_source_file            c4ce01446d2.cif
_cod_data_source_block           Form_I
_cod_depositor_comments
;
The following automatic conversions were performed:

'_chemical_melting_point' value '466-467' was changed to '466.5(5)' -
the average value was taken and precision was estimated.

Automatic conversion script
Id: cif_fix_values 2281 2013-09-26 08:29:07Z andrius 

 Adding full bibliography for 7217661--7217662.cif.
;
_cod_original_sg_symbol_H-M      P-1
_cod_database_code               7217661
loop_
_symmetry_equiv_pos_as_xyz
'x, y, z'
'-x, -y, -z'
loop_
_atom_site_label
_atom_site_type_symbol
_atom_site_fract_x
_atom_site_fract_y
_atom_site_fract_z
_atom_site_U_iso_or_equiv
_atom_site_adp_type
_atom_site_occupancy
_atom_site_symmetry_multiplicity
_atom_site_calc_flag
Cl1 Cl 0.36289(4) 0.84036(3) 0.92780(3) 0.02890(10) Uani 1 1 d
F1 F 0.38880(9) 1.08785(8) 0.80103(6) 0.02642(17) Uani 1 1 d
N1 N 0.76045(12) 0.54876(11) 0.33582(8) 0.0188(2) Uani 1 1 d
C2 C 0.69740(15) 0.65667(13) 0.35934(10) 0.0197(2) Uani 1 1 d
N3 N 0.65118(12) 0.69656(10) 0.45363(8) 0.0179(2) Uani 1 1 d
C4 C 0.67129(13) 0.61582(12) 0.53397(9) 0.0148(2) Uani 1 1 d
N4 N 0.62740(11) 0.64874(10) 0.63222(8) 0.0162(2) Uani 1 1 d
C5 C 0.76388(13) 0.40384(12) 0.60444(9) 0.0148(2) Uani 1 1 d
C6 C 0.83003(13) 0.29009(12) 0.58549(9) 0.0151(2) Uani 1 1 d
O6 O 0.86115(10) 0.19882(8) 0.65967(6) 0.01706(17) Uani 1 1 d
C7 C 0.87132(13) 0.25908(12) 0.48081(9) 0.0154(2) Uani 1 1 d
O7 O 0.93085(10) 0.14087(9) 0.47258(6) 0.01955(18) Uani 1 1 d
C8 C 0.84878(13) 0.34584(12) 0.40035(9) 0.0162(2) Uani 1 1 d
C9 C 0.78206(13) 0.46508(12) 0.41924(9) 0.0153(2) Uani 1 1 d
C10 C 0.73860(12) 0.49358(11) 0.52158(9) 0.0146(2) Uani 1 1 d
C11 C 0.56557(13) 0.76356(12) 0.66809(9) 0.0151(2) Uani 1 1 d
C12 C 0.50223(13) 0.74997(12) 0.76475(9) 0.0167(2) Uani 1 1 d
C13 C 0.44336(13) 0.85862(13) 0.80875(9) 0.0180(2) Uani 1 1 d
C14 C 0.44576(14) 0.98097(12) 0.75644(10) 0.0187(2) Uani 1 1 d
C15 C 0.50562(14) 0.99540(12) 0.66055(9) 0.0193(2) Uani 1 1 d
C16 C 0.56797(14) 0.88762(12) 0.61607(9) 0.0178(2) Uani 1 1 d
C17 C 0.82814(14) 0.22957(12) 0.76729(9) 0.0162(2) Uani 1 1 d
C18 C 0.88656(14) 0.12239(12) 0.83611(9) 0.0170(2) Uani 1 1 d
C19 C 1.06318(14) 0.16808(12) 0.87308(9) 0.0181(2) Uani 1 1 d
N20 N 1.09799(11) 0.28903(10) 0.95630(7) 0.0158(2) Uani 1 1 d
C21 C 1.25651(14) 0.37529(13) 0.96157(10) 0.0203(2) Uani 1 1 d
C22 C 1.28182(15) 0.50043(13) 1.04670(10) 0.0208(3) Uani 1 1 d
O23 O 1.25847(9) 0.45460(9) 1.15139(6) 0.01839(18) Uani 1 1 d
C24 C 1.10331(14) 0.36932(13) 1.14539(9) 0.0200(2) Uani 1 1 d
C25 C 1.07870(14) 0.24178(13) 1.06344(9) 0.0188(2) Uani 1 1 d
C26 C 0.97682(15) 0.10237(13) 0.37117(10) 0.0201(2) Uani 1 1 d
H2 H 0.6809(17) 0.7162(16) 0.3025(12) 0.024(4) Uiso 1 1 d
H4 H 0.6332(17) 0.5901(16) 0.6794(12) 0.020(4) Uiso 1 1 d
H5 H 0.7355(17) 0.4225(15) 0.6733(12) 0.021(3) Uiso 1 1 d
H8 H 0.8778(17) 0.3283(15) 0.3308(12) 0.021(3) Uiso 1 1 d
H12 H 0.4981(16) 0.6642(16) 0.8002(11) 0.020(3) Uiso 1 1 d
H15 H 0.5051(17) 1.0801(17) 0.6267(12) 0.025(4) Uiso 1 1 d
H16 H 0.6104(17) 0.8997(15) 0.5517(12) 0.020(3) Uiso 1 1 d
H17A H 0.7159(17) 0.2227(14) 0.7650(11) 0.016(3) Uiso 1 1 d
H17B H 0.8849(16) 0.3250(15) 0.7953(11) 0.016(3) Uiso 1 1 d
H18A H 0.8594(16) 0.0287(15) 0.7941(11) 0.019(3) Uiso 1 1 d
H18B H 0.8316(16) 0.1134(14) 0.8985(11) 0.017(3) Uiso 1 1 d
H19A H 1.1087(16) 0.0861(15) 0.8986(11) 0.019(3) Uiso 1 1 d
H19B H 1.1136(16) 0.1992(15) 0.8106(12) 0.019(3) Uiso 1 1 d
H21A H 1.2680(17) 0.4103(15) 0.8919(12) 0.021(3) Uiso 1 1 d
H21B H 1.3369(18) 0.3185(16) 0.9796(12) 0.023(4) Uiso 1 1 d
H22A H 1.3885(18) 0.5569(15) 1.0548(11) 0.022(3) Uiso 1 1 d
H22B H 1.2072(17) 0.5621(15) 1.0269(11) 0.021(3) Uiso 1 1 d
H24A H 1.0271(17) 0.4281(15) 1.1269(11) 0.021(3) Uiso 1 1 d
H24B H 1.0938(17) 0.3406(15) 1.2184(12) 0.021(3) Uiso 1 1 d
H25A H 1.1542(17) 0.1819(15) 1.0852(11) 0.020(3) Uiso 1 1 d
H25B H 0.9721(18) 0.1842(16) 1.0629(12) 0.023(4) Uiso 1 1 d
H26A H 0.8879(18) 0.0890(15) 0.3112(12) 0.024(4) Uiso 1 1 d
H26B H 1.0102(17) 0.0146(16) 0.3809(11) 0.021(3) Uiso 1 1 d
H26C H 1.0642(18) 0.1777(16) 0.3542(12) 0.024(4) Uiso 1 1 d
loop_
_atom_type_symbol
_atom_type_description
_atom_type_scat_dispersion_real
_atom_type_scat_dispersion_imag
_atom_type_scat_source
C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
F F 0.0171 0.0103 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
Cl Cl 0.1484 0.1585 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4'
loop_
_geom_angle_atom_site_label_1
_geom_angle_atom_site_label_2
_geom_angle_atom_site_label_3
_geom_angle
C2 N1 C9 114.96(10)
N1 C2 N3 129.08(11)
N1 C2 H2 116.5(9)
N3 C2 H2 114.4(9)
C4 N3 C2 116.08(10)
N3 C4 N4 119.79(10)
N3 C4 C10 121.86(10)
N4 C4 C10 118.35(10)
C4 N4 C11 130.43(10)
C4 N4 H4 117.0(10)
C11 N4 H4 112.5(10)
C6 C5 C10 120.42(10)
C6 C5 H5 119.5(9)
C10 C5 H5 120.1(9)
O6 C6 C5 125.06(10)
O6 C6 C7 114.81(10)
C5 C6 C7 120.13(10)
C6 O6 C17 116.72(9)
O7 C7 C8 126.27(10)
O7 C7 C6 113.77(10)
C8 C7 C6 119.96(10)
C7 O7 C26 117.70(9)
C7 C8 C9 120.49(10)
C7 C8 H8 121.2(9)
C9 C8 H8 118.3(9)
N1 C9 C10 122.08(10)
N1 C9 C8 118.53(10)
C10 C9 C8 119.39(10)
C9 C10 C5 119.58(10)
C9 C10 C4 115.95(10)
C5 C10 C4 124.47(10)
C12 C11 C16 119.59(10)
C12 C11 N4 115.57(10)
C16 C11 N4 124.82(10)
C13 C12 C11 120.14(11)
C13 C12 H12 119.8(9)
C11 C12 H12 120.1(8)
C12 C13 C14 119.87(11)
C12 C13 Cl1 119.94(9)
C14 C13 Cl1 120.18(9)
F1 C14 C15 119.83(10)
F1 C14 C13 119.37(10)
C15 C14 C13 120.80(11)
C14 C15 C16 120.00(11)
C14 C15 H15 118.7(9)
C16 C15 H15 121.3(9)
C15 C16 C11 119.59(11)
C15 C16 H16 119.1(9)
C11 C16 H16 121.3(9)
O6 C17 C18 106.52(9)
O6 C17 H17A 109.4(8)
C18 C17 H17A 112.1(8)
O6 C17 H17B 109.3(8)
C18 C17 H17B 109.7(8)
H17A C17 H17B 109.7(11)
C17 C18 C19 110.91(9)
C17 C18 H18A 109.1(8)
C19 C18 H18A 111.0(8)
C17 C18 H18B 108.9(8)
C19 C18 H18B 110.1(8)
H18A C18 H18B 106.8(11)
N20 C19 C18 110.22(9)
N20 C19 H19A 112.1(8)
C18 C19 H19A 111.4(8)
N20 C19 H19B 107.8(8)
C18 C19 H19B 108.4(8)
H19A C19 H19B 106.7(11)
C25 N20 C21 108.64(9)
C25 N20 C19 111.16(9)
C21 N20 C19 112.68(9)
N20 C21 C22 109.57(10)
N20 C21 H21A 108.9(9)
C22 C21 H21A 109.1(9)
N20 C21 H21B 111.2(9)
C22 C21 H21B 109.5(9)
H21A C21 H21B 108.6(12)
O23 C22 C21 111.54(10)
O23 C22 H22A 106.4(8)
C21 C22 H22A 111.4(9)
O23 C22 H22B 107.9(8)
C21 C22 H22B 110.4(8)
H22A C22 H22B 109.0(12)
C24 O23 C22 109.57(9)
O23 C24 C25 110.49(10)
O23 C24 H24A 108.9(9)
C25 C24 H24A 111.5(8)
O23 C24 H24B 106.2(8)
C25 C24 H24B 111.3(8)
H24A C24 H24B 108.2(12)
N20 C25 C24 109.64(9)
N20 C25 H25A 110.4(8)
C24 C25 H25A 110.1(8)
N20 C25 H25B 110.7(8)
C24 C25 H25B 108.4(8)
H25A C25 H25B 107.6(12)
O7 C26 H26A 111.1(9)
O7 C26 H26B 104.8(9)
H26A C26 H26B 110.8(12)
O7 C26 H26C 110.5(8)
H26A C26 H26C 108.3(12)
H26B C26 H26C 111.2(12)
loop_
_geom_bond_atom_site_label_1
_geom_bond_atom_site_label_2
_geom_bond_distance
Cl1 C13 1.7335(12)
F1 C14 1.3579(13)
N1 C2 1.3141(16)
N1 C9 1.3776(14)
C2 N3 1.3545(15)
C2 H2 0.958(15)
N3 C4 1.3268(15)
C4 N4 1.3722(15)
C4 C10 1.4364(15)
N4 C11 1.4072(15)
N4 H4 0.848(16)
C5 C6 1.3687(16)
C5 C10 1.4177(16)
C5 H5 0.944(15)
C6 O6 1.3608(13)
C6 C7 1.4326(15)
O6 C17 1.4380(13)
C7 O7 1.3562(14)
C7 C8 1.3709(16)
O7 C26 1.4297(14)
C8 C9 1.4187(16)
C8 H8 0.952(15)
C9 C10 1.4086(15)
C11 C12 1.3979(16)
C11 C16 1.3986(16)
C12 C13 1.3787(16)
C12 H12 0.962(15)
C13 C14 1.3858(17)
C14 C15 1.3748(17)
C15 C16 1.3924(17)
C15 H15 0.946(16)
C16 H16 0.934(15)
C17 C18 1.5159(15)
C17 H17A 0.974(14)
C17 H17B 0.972(14)
C18 C19 1.5263(16)
C18 H18A 0.985(14)
C18 H18B 0.970(14)
C19 N20 1.4676(14)
C19 H19A 1.011(14)
C19 H19B 0.981(15)
N20 C25 1.4615(14)
N20 C21 1.4619(15)
C21 C22 1.5183(17)
C21 H21A 0.964(15)
C21 H21B 0.994(15)
C22 O23 1.4344(14)
C22 H22A 0.973(15)
C22 H22B 0.993(15)
O23 C24 1.4327(14)
C24 C25 1.5115(17)
C24 H24A 0.981(15)
C24 H24B 0.980(15)
C25 H25A 0.992(15)
C25 H25B 0.986(15)
C26 H26A 0.991(15)
C26 H26B 0.964(15)
C26 H26C 0.999(15)
loop_
_geom_hbond_atom_site_label_D
_geom_hbond_atom_site_label_H
_geom_hbond_atom_site_label_A
_geom_hbond_distance_DH
_geom_hbond_distance_HA
_geom_hbond_distance_DA
_geom_hbond_angle_DHA
_geom_hbond_site_symmetry_A
C25 H25B Cl1 0.986(15) 2.930(15) 3.8236(13) 151.1(11) 2_667
C26 H26B O7 0.964(15) 2.512(15) 3.3124(15) 140.4(11) 2_756
C26 H26B O6 0.964(15) 2.604(15) 3.5197(15) 158.7(11) 2_756
C2 H2 F1 0.958(15) 2.496(16) 3.4220(14) 162.7(12) 2_676
C12 H12 O23 0.962(15) 2.655(14) 3.2966(14) 124.5(10) 2_767
C5 H5 O23 0.944(15) 2.412(15) 3.3091(14) 158.6(12) 2_767
N4 H4 O23 0.848(16) 2.308(15) 3.0609(12) 148.2(13) 2_767
loop_
_geom_torsion_atom_site_label_1
_geom_torsion_atom_site_label_2
_geom_torsion_atom_site_label_3
_geom_torsion_atom_site_label_4
_geom_torsion
C9 N1 C2 N3 0.02(19)
N1 C2 N3 C4 -0.28(19)
C2 N3 C4 N4 -179.93(10)
C2 N3 C4 C10 0.19(16)
N3 C4 N4 C11 -2.82(18)
C10 C4 N4 C11 177.07(10)
C10 C5 C6 O6 179.08(10)
C10 C5 C6 C7 -1.30(16)
C5 C6 O6 C17 -3.07(16)
C7 C6 O6 C17 177.28(9)
O6 C6 C7 O7 1.73(14)
C5 C6 C7 O7 -177.93(10)
O6 C6 C7 C8 -178.44(10)
C5 C6 C7 C8 1.90(16)
C8 C7 O7 C26 0.77(16)
C6 C7 O7 C26 -179.41(10)
O7 C7 C8 C9 178.66(10)
C6 C7 C8 C9 -1.15(16)
C2 N1 C9 C10 0.33(16)
C2 N1 C9 C8 179.67(10)
C7 C8 C9 N1 -179.52(10)
C7 C8 C9 C10 -0.16(16)
N1 C9 C10 C5 -179.91(10)
C8 C9 C10 C5 0.75(16)
N1 C9 C10 C4 -0.40(16)
C8 C9 C10 C4 -179.73(10)
C6 C5 C10 C9 -0.01(16)
C6 C5 C10 C4 -179.48(10)
N3 C4 C10 C9 0.12(15)
N4 C4 C10 C9 -179.76(10)
N3 C4 C10 C5 179.61(10)
N4 C4 C10 C5 -0.27(16)
C4 N4 C11 C12 166.84(11)
C4 N4 C11 C16 -15.05(19)
C16 C11 C12 C13 -0.38(17)
N4 C11 C12 C13 177.84(10)
C11 C12 C13 C14 0.59(17)
C11 C12 C13 Cl1 179.26(9)
C12 C13 C14 F1 -179.40(10)
Cl1 C13 C14 F1 1.94(16)
C12 C13 C14 C15 0.31(18)
Cl1 C13 C14 C15 -178.35(9)
F1 C14 C15 C16 178.28(10)
C13 C14 C15 C16 -1.42(18)
C14 C15 C16 C11 1.62(17)
C12 C11 C16 C15 -0.72(17)
N4 C11 C16 C15 -178.77(11)
C6 O6 C17 C18 -174.73(9)
O6 C17 C18 C19 81.34(11)
C17 C18 C19 N20 72.27(12)
C18 C19 N20 C25 82.60(11)
C18 C19 N20 C21 -155.17(9)
C25 N20 C21 C22 -58.15(12)
C19 N20 C21 C22 178.21(9)
N20 C21 C22 O23 58.08(13)
C21 C22 O23 C24 -57.86(13)
C22 O23 C24 C25 58.84(12)
C21 N20 C25 C24 59.77(12)
C19 N20 C25 C24 -175.69(9)
O23 C24 C25 N20 -60.69(13)
loop_
_cod_related_entry_id
_cod_related_entry_database
_cod_related_entry_code
1 PubChem 123631
